Weetzie Bat, My Secret Agent Lover Man, Dirk, Duck, Valentine Jah-Love, and Ping Chong have traveled to South American to make a movie. This means Cherokee Bat, her almost-sister Witch Baby, and Cherokee's boyfriend, Raphael, have been left home with only a family friend, Coyote, nearby for guidance. When Witch Baby begins to sink into depression, Cherokee and Coyote come up with a mystical way to save her. Witch Baby's recovery is further aided by the return of her true love, Angel Juan Perez. Soon Cherokee, Witch Baby, Raphael, and Angel Juan form a rock band called the Goat Guys and Cherokee creates mystical gifts to give all her bandmates the confidence to play in front of an audience. The Goat Guys are a success, but they discover that the more famous they become the more they lose of themselves. Will Cherokee be able to pull herself and her friends away from their destructive ways?